Integrative analysis reveals extensive association between microRNA expression and mRNA-protein translation [mRNA]

ABSTRACT: Transcription signatures have been used to stratify breast cancer patients into clinically distinct subgroups. However, transcription alone does not determine protein expression. Of potentially equal importance for determining the tumor phenotype is the rate at which transcripts are translated to form protein. Protein translation is controlled to a major degree by miRNA, and cancer cells may deregulate the expression of key genes by altering the activity of relevant miRNAs. The importance of miRNA deregulation and the extent to which multiple miRNAs coordinately deregulate key proteins in breast cancer is only partly understood. To gain such insight, we analyzed genome-wide miRNA expression and mRNA/protein expression for a panel of 105 selected cancer related genes in breast carcinomas fr

ORGANISM(S): Homo sapiens

SUBMITTER: Miriam Aure 

PROVIDER: E-GEOD-58212 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress