Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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RNAi profiling of human cancer cell lines depleted for c-MYC depletion

ABSTRACT: Affymetrix Hu133 GeneCHIP Microarray data for Control and c-MYC knock-down (KD) human cancer cell lines. Data related to article 'Novel c-MYC target genes mediate differential effects on cell proliferation and migration', from D. CAPPELLEN et al., EMBO Reports; Note: Samples GSM136093 and GSM136094 (Hela cell line, expt 1) were hybridized and normalized separately from the other 18 Samples. Experiment Overall Design: The cells were harvested 3 days after LacZ (Control) and c-MYC (c-MYC KD) small interfering RNA transfection, and total RNA was used for microarray-based global gene expression profiling.

ORGANISM(S): Homo sapiens

SUBMITTER: David Cappellen 

PROVIDER: E-GEOD-5823 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Novel c-MYC target genes mediate differential effects on cell proliferation and migration.

Cappellen David D   Schlange Thomas T   Bauer Matthieu M   Maurer Francisca F   Hynes Nancy E NE  

EMBO reports 20061208 1

The developmental and oncogenic roles of MYC proteins are well established, but the transcriptional targets mediating their functions remain elusive. Using small interfering RNA-mediated knockdown in breast and cervix carcinoma cell lines, which overexpress c-MYC, we show that c-MYC independently controls metabolism and cell proliferation, and can, depending on the cells, promote or inhibit migration. We identified new c-MYC target genes in these cell lines, and show that selective regulation of  ...[more]

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