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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Liver Transcriptomics data from mouse model with Features of Post-traumatic Stress Disorder

ABSTRACT: We have used a social defeat (SD) mouse model of post-traumatic stress disorder (PTSD) that is based on a brief exposure of a mouse to the aggressor mice for either 5 d or 10 d stress periods. Mice simulating aspects of posttraumatic stress disorder exhibit behavioral changes, body weight gain, increased body temperature, and inflammatory and fibrotic histopathologies and transcriptomic changes of heart tissue. Liver tissue of these mice was subjected to mRNA analysis. Transcriptomic analysis of liver indicated chronic toxicities and metabolic alterations in aggressor-exposed mice that possibly contributed to the persistent metabolic disturbance Two-condition experiment, C57BL6/J mice Biological replicates: 4-6 control replicates, 5-6 stressed replicates.

ORGANISM(S): Mus musculus

SUBMITTER: Meskerem Jibitu

PROVIDER: E-GEOD-58275 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Liver Transcriptomics data from mouse model with Features of Post-traumatic Stress Disorder

Project description:We have used a social defeat (SD) mouse model of post-traumatic stress disorder (PTSD) that is based on a brief exposure of a mouse to the aggressor mice for either 5 d or 10 d stress periods. Mice simulating aspects of posttraumatic stress disorder exhibit behavioral changes, body weight gain, increased body temperature, and inflammatory and fibrotic histopathologies and transcriptomic changes of heart tissue. Liver tissue of these mice was subjected to mRNA analysis. Transcriptomic analysis of liver indicated chronic toxicities and metabolic alterations in aggressor-exposed mice that possibly contributed to the persistent metabolic disturbance

2014-06-07 | GSE58275 | GEO

Transcriptome profiling of spleen, blood and hemi-brain of social stressed C57B6 mice exhibiting PTSD like features

Project description:Social stress mouse models were used to simulate human post-traumatic stress disorder (PTSD). C57B/6 mice exposed to SJL aggressor mice exhibited behaviors accepted as PTSD-in-mouse phenotype: 'frozen' motion, aggressor's barrier avoidance, startled jumping, and retarded locomotion. Transcripts in spleen, blood and hemi-brain of stressed and control C57B/6 mice were analyzed using Agilent's mouse genome-wide arrays. C57B6 mice were exposed to SJL aggressor mice for periods of 5 days and 10 days (6 hours each day) to induce anxiety/stress which parallels to PTSD in human. Organs, blood and brain regions were collected after 24 hours and 1.5 week of post 5 days social defeat period; and 24 hour and 6 weeks post 10 days social stress period.

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Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder

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2015-04-20 | E-GEOD-45035 | biostudies-arrayexpress

Gene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study2]

2013-12-04 | E-GEOD-52871 | biostudies-arrayexpress

miRNA expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study2]

Project description:Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our time-course study (Study II) with three experimental conditions where we varied the length of time that subservient mice were exposed to aggressor mice with the same length of rest time after the exposure (1day). The conditions included were 1day-exposure (T1R1), 2day-exposure (T2R1) and 3day-exposure (T3R1). We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggressor mice and the length of rest time after the exposure. The conditions included were short exposure-short rest (T5R1-T indicates the number of days of trauma exposure; R indicates the number of days of rest after exposure), short exposure-long rest (T5R10), long exposure-short rest (T10R1) and long exposure-long rest (T10R42)

2013-12-04 | E-GEOD-52872 | biostudies-arrayexpress

Gene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]

2013-12-04 | E-GEOD-52866 | biostudies-arrayexpress

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2013-12-04 | E-GEOD-52869 | biostudies-arrayexpress

Transcriptome profiling of spleen, blood and hemi-brain of social stressed C57B6 mice exhibiting PTSD like features

2015-12-31 | GSE68076 | GEO

Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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2016-08-03 | E-GEOD-64004 | biostudies-arrayexpress

Expression data from ileum of mice suffered from subchronic and mild social defeat stress

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