Gene expression profiling classifies lung squamous cell carcinomas with N1 positive lymph nodes

ABSTRACT: Using gene expression microarrays, we tested whether lung SCCs that have metastasised to loco-regional lymph nodes (N1/2m) are different to those that directly invade and involve local nodes (N1d). Using 22,323 element microarrays, a non-parametric test identified 126 genes/transcripts that discriminated between N0 (n=35) and N1/2m (n=16) tumours (Wilcoxon-Mann-Whitney U test, P<0.01). Hiearchical clustering of all 59 tumours (including 8 N1d tumours) demonstrated the N1d tumours clustered with the N0 tumours rather than the N1/2m tumours. Next, we built class prediction models from the 35 N0 tumours and 16 N1/2m tumours to predict the class of N1d tumours. All models consistently classified N1d tumours as similar to N0 tumours. This could explain some of the variable response of some N1 t

ORGANISM(S): Homo sapiens

SUBMITTER: Jill Larsen 

PROVIDER: E-GEOD-5828 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress