Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

A Gpr120 Selective Agonist Improves Insulin Resistance and Chronic Inflammation


ABSTRACT: We report that a high affinity, selective, small molecule Gpr120 agonist (cpdA), exerts potent anti-inflammatory effects on macrophages in vitro, and in obese mice in vivo. Gpr120 agonist treatment of high fat diet (HFD)/obese mice causes improved glucose tolerance, decreased hyperinsulinemia, increased insulin sensitivity and decreased hepatic steatosis. This suggests that Gpr120 agonists could become new insulin sensitizing drugs for the treatment of Type 2 diabetes and other human insulin resistant states in the future. Examination of effects of DHA and compound A on primary macrophages stimulated by LPS, 3 replicates for each condition

ORGANISM(S): Mus musculus

SUBMITTER: Roman Sasik 

PROVIDER: E-GEOD-58282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2014-06-07 | GSE58282 | GEO
2012-02-21 | E-GEOD-26637 | biostudies-arrayexpress
2012-02-21 | GSE26637 | GEO
2014-06-12 | E-GEOD-55836 | biostudies-arrayexpress
2021-08-11 | GSE144414 | GEO
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
2021-04-07 | GSE141432 | GEO
2014-06-12 | GSE55836 | GEO
2015-09-18 | E-GEOD-56022 | biostudies-arrayexpress
2022-11-09 | GSE202697 | GEO