Mouse brain tissue after methanol and normal saline treatment

ABSTRACT: We recently showed that methanol emitted by wounded plants might function as a signaling molecule for plant-to-plant and plant-to-animal communications. In mammals, methanol is considered a poison because the enzyme alcohol dehydrogenase (ADH) converts methanol into toxic formaldehyde. However, the detection of methanol in the blood and exhaled air of healthy volunteers suggests that methanol may be a chemical with specific functions rather than a metabolic waste product. Using a genome-wide analysis of the mouse brain, we demonstrated that an increase in blood methanol concentration led to a change in the accumulation of mRNAs from genes primarily involved in detoxification processes and regulation of the alcohol/aldehyde dehydrogenases gene cluster. Removal of the intestine signifi

ORGANISM(S): Mus musculus

SUBMITTER: Anastasia Shindyapina 

PROVIDER: E-GEOD-58303 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress