Human leukocytes from 6 volunteers before and 2h after pectin capsules consumption (II)

ABSTRACT: Methanol (MeOH) is considered to be a poison in humans because of the alcohol dehydrogenase (ADH)-mediated conversion of MeOH into toxic formaldehyde (FA). Our recent genome-wide analysis of the mouse brain demonstrated that an increase in endogenous MeOH after ADH inhibition led to a significant increase in the plasma MeOH concentration and the modification of mRNA synthesis. These findings suggest endogenous MeOH involvement in homeostasis regulation by controlling mRNA levels. Here, we demonstrate directly that study volunteers displayed increasing concentrations of MeOH and FA in their blood plasma when consuming citrus pectin, ethanol and red wine. A microarray analysis of white blood cells (WBC) in volunteers after pectin intake showed various responses for 30 differentially regulate

ORGANISM(S): Homo sapiens

SUBMITTER: Anastasia Shindyapina 

PROVIDER: E-GEOD-58349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress