The BCL6 RD2 domain governs commitment of activated B-cells to form germinal centers

ABSTRACT: Our data demonstrated that Bcl6 directly binds and represses trafficking receptors S1pr1 and Grp183 by recruiting Hdac2 through the RD2 domain. Deregulation of these genes impairs B-cell migration and may contribute to the Germinal Center failure in Bcl6RD2MUT mice. RNAseq was performed in endogenous BCL6-depleted OCI-LY1 cells rescued with either WT or RD mutant BCL6 (N=3 for each group).

ORGANISM(S): Homo sapiens

SUBMITTER: Yanwen Jiang 

PROVIDER: E-GEOD-58365 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress