Genome-wide identification of PPARG binding sites in NCI-H2347 and NCI-H1993 cell lines

ABSTRACT: While the regulation of metabolic enzymes by oncogenic drivers or tumor suppressors has been intensively studied over recent years, our understanding of how metabolic processes directly regulate cell proliferation has remained fragmentary. Here we show how the alteration of metabolism directly affects cell cycle progression in cancer cells. We found that activation of the nuclear receptor peroxisome-proliferation activated receptor gamma (PPARM-NM-3), a transcriptional master regulator of lipid metabolism, inhibits the growth of lung adenocarcinoma cells by triggering a metabolic switch that inhibits pyruvate oxidation and reduces glutathione levels. These PPARM-NM-3-induced metabolic changes result in a marked increase of reactive oxygen species (ROS) levels that lead to rapid hypophospho

ORGANISM(S): Homo sapiens

SUBMITTER: Ralf Kittler 

PROVIDER: E-GEOD-58382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress