Cyclic mechanical stretch-induced gene expression

ABSTRACT: With gene expression profiling it was aimed to identify the differentially expressed genes associated with the regulation of the cytoskeleton to investigate the stretch-induced cell alignment mechanism. A whole genome microarray based analysis of the stretch-induced gene expression changes was done. Gene expression was measured at the beginning of the alignment process showing first reoriented cells after 5 h stretching and at the end after 24 h, where nearly all cells are aligned. Cyclic mechanical stretching of cells results in cellular alignment perpendicular to the stretch direction regulating cellular response. This stress response is assumed to be an adaptation mechanism to reduce extensive stretching but also acts as architectural restructuring changing performance and biomechanics

ORGANISM(S): Homo sapiens

SUBMITTER: Maria Reichenbach 

PROVIDER: E-GEOD-58389 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress