Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christopher Frank
PROVIDER: E-GEOD-58398 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wijayatunge Ranjula R Chen Liang-Fu LF Cha Young May YM Zannas Anthony S AS Frank Christopher L CL West Anne E AE
Molecular and cellular neurosciences 20140628
Enzymes that regulate histone lysine methylation play important roles in neuronal differentiation, but little is known about their contributions to activity-regulated gene transcription in differentiated neurons. We characterized activity-regulated expression of lysine demethylases and lysine methyltransferases in the hippocampus of adult male mice following pilocarpine-induced seizure. Pilocarpine drove a 20-fold increase in mRNA encoding the histone H3 lysine 27-specific demethylase Kdm6b sele ...[more]