The cistrome and transcriptome landscape of androgen receptor splice variants in castration-resistant prostate cancer cells

ABSTRACT: The spliced variant forms of androgen receptor (AR-Vs) have been identified recently in castration-resistant prostate cancer (CRPC) cell lines and clinical samples. Here we identified the cistrome and transcriptome landscape of AR-Vs in CRPC cell lines and determine the clinical significance of AR variants regulated gene.The AR variants binding sites can be identified in 22Rv1 cell line in the absence of androgen. Knocking down full-length AR (AR-FL) doesn't affect AR-Vs binding sites in genome-wide. A set of genes were identified to be regulated uniquely by AR-Vs, but not by AR-FL in androgen-depleted condition. Integrated analysis showed that some genes may be modulated by AR-Vs directly. Unsupervised clustering analysis demonstrated that AR variants gene signature can separate not only

ORGANISM(S): Homo sapiens

SUBMITTER: LIGUO WANG 

PROVIDER: E-GEOD-58478 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress