Transcription profiling of human oocytes from patients with polycystic ovary syndrome

ABSTRACT: Polycystic ovary syndrome (PCOS), the most common cause of anovulatory infertility, is characterized by increased ovarian androgen production, arrested follicle development, and is frequently associated with insulin resistance. These PCOS phenotypes are associated with exaggerated ovarian responsiveness to FSH and increased pregnancy loss. To examine whether the perturbations in follicle growth and the intrafollicular environment affects development of the mature PCOS oocyte, genes that are differentially expressed in PCOS compared to normal oocytes were defined using microarray analysis. This analysis detected approximately 8000 transcripts. Hierarchical clustering and principal component analysis revealed differences in global gene expression profiles between normal and PCOS oocytes.

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Wood 

PROVIDER: E-GEOD-5850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress