BolA is a transcriptional switch that turns off motility and turns on biofilm development

ABSTRACT: Bacteria are extremely versatile organisms which rapidly adapt to changing environments. When Escherichia coli cells switch from planktonic growth to biofilm, flagellum formation is turned off, and the production of fimbriae and extracellular polysaccharides is switched on. Here we show that BolA protein is a new bacterial transcription factor which modulates the switch from planktonic to sessile lifestyle. BolA negatively modulates flagella biosynthesis and thus swimming capacity. Furthermore, BolA overexpression favors biofilm formation and involvesinvolving fimbriae-like adhesins and curli production. Our results unraveled for the first time that BolA is a protein with high affinity to DNA, involved in the regulation of several genes of E. coli at a genome-wide scale level. Moreover, th

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

SUBMITTER: Cecilia Arraiano 

PROVIDER: E-GEOD-58509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress