Early remodeling of the neocortex upon episodic memory encoding

ABSTRACT: Understanding the mechanisms by which long-term memories are formed and stored in the brain represents a central aim of neuroscience. Prevailing theory suggests that long-term memory encoding involves early plasticity within hippocampal circuits, while reorganization of the neocortex is thought to occur weeks to months later to subserve remote memory storage. Here we report that long-term memory encoding can elicit early transcriptional, structural and functional remodeling of the neocortex. Parallel studies using genome-wide RNA-sequencing, ultrastructural imaging, and whole-cell recording in wild-type mice suggest that contextual fear conditioning initiates a transcriptional program in the medial prefrontal cortex (mPFC) that is accompanied by rapid expansion of the synaptic active zone

ORGANISM(S): Mus musculus

SUBMITTER: Li-Huei Tsai 

PROVIDER: E-GEOD-58510 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress