Identification of B52 potential mRNA targets

ABSTRACT: Deciphering the role of alternative splicing in developmental processes relies on the identification of key genes whose expression is controlled by splicing regulators throughout growth of a whole organism. Targeting expression of five SR proteins in the developing eye of Drosophila allowed us to show that these splicing factors induce various phenotypic alterations concerning eye organogenesis and viability. Although both dASF/SF2 and B52 caused defects in ommatidia structure, only B52 impairs normal photoreceptor axons projection and neurogenesis in visual ganglia. Consistently, microarray analyses revealed that many of the B52 targets are involved in brain organogenesis and we show that their splicing profile is altered both in B52 loss and gain of function. Conversely, a large proporti

ORGANISM(S): Drosophila melanogaster

SUBMITTER: johann Soret 

PROVIDER: E-GEOD-5858 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress