Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of human lymphoblasts from HapMap populations CEU, CHB, JPY reveals allelic differences account for gene expression differences among populations

ABSTRACT: Expression level of genes in lymphoblasts from individuals in three HapMap populations (CEU, CHB, JPT) were compared. More than 1,000 genes were found to be significantly different (Pc<0.05) in mean expression level between the CEU and CHB+JPT samples. Experiment Overall Design: Gene expression analysis using Affymetrix Human Focus arrays; comparison of expression levels of genes by t-test.

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Morley 

PROVIDER: E-GEOD-5859 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Common genetic variants account for differences in gene expression among ethnic groups.

Spielman Richard S RS   Bastone Laurel A LA   Burdick Joshua T JT   Morley Michael M   Ewens Warren J WJ   Cheung Vivian G VG  

Nature genetics 20070107 2

Variation in DNA sequence contributes to individual differences in quantitative traits, but in humans the specific sequence variants are known for very few traits. We characterized variation in gene expression in cells from individuals belonging to three major population groups. This quantitative phenotype differs significantly between European-derived and Asian-derived populations for 1,097 of 4,197 genes tested. For the phenotypes with the strongest evidence of cis determinants, most of the va  ...[more]

Similar Datasets

Unknown Allelic Differences Account for Gene Expression Differences Among Population.
2007-01-07 | GSE5859 | GEO
Unknown Illumina HapMap CHB and JPT (1M-Duo)
2009-07-27 | GSE16895 | GEO
Unknown Illumina HapMap CEU (1M-Duo)
2009-07-27 | GSE16894 | GEO
Unknown Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations.
| S-EPMC2947108 | biostudies-literature
Unknown Custom array CGH validation of de novo CNVs in CEU HapMap samples
2010-09-01 | GSE23575 | GEO
Unknown Gene expression from CEPH-Utah,CHB+JPT, and YRI individuals to examine gene expression correlation
2009-08-13 | GSE12526 | GEO
Unknown Genome-wide baseline microRNA expression quantification in HapMap phase I CEU and YRI samples
2012-07-29 | GSE34406 | GEO
Transcriptomics Custom array CGH validation of de novo CNVs in CEU HapMap samples
2010-09-01 | E-GEOD-23575 | biostudies-arrayexpress
Transcriptomics Genotyping of human lymphoblastoid cell lines from CEU and YRI HapMap individuals
2010-03-02 | E-TABM-927 | biostudies-arrayexpress
Transcriptomics CGH validation of de novo CNVs in asthma and CEU HapMap samples
2010-09-01 | E-GEOD-23645 | biostudies-arrayexpress