Epigenome Wide Association Study unveils differential methylation of Leukocyte cell adhesion molecules in neonatal sepsis

ABSTRACT: DNA methylation is the current strategy in the field of biomarker discovery due to its prognostic efficiency. Its role in prognosis and early diagnosis has been recognized in various types of cancer. Sepsis still remains one of the major causes of neonatal mortality due to the lack of sensitive diagnostic and prognostic biomarkers. Delay in sepsis diagnosis leads to treatment difficulties and poor outcomes. In this study, we have done an epigenome wide search to identify potential markers for prognosis of neonatal sepsis which may improve the treatment strategies. Illumina 450K methylation microarray revealed that the genes involved in transendothelial leukocyte migration were differentially methylated in septic newborns compared to non-septic newborns, especially the Protocadherin Beta gr

ORGANISM(S): Homo sapiens

SUBMITTER: Benet Dhas 

PROVIDER: E-GEOD-58651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress