Super-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins

ABSTRACT: Here, we investigate the role of enhancers in myofibroblasts, a cell type that dominates the pathogenesis and progression of tissue fibrosis. We reveal that bromodomain and extra-terminal family members (BETs), an important group of epigenetic readers, are critical for super-enhancer-mediated pro-fibrotic gene expression in hepatic stellate cells (HSCs, lipid-containing liver-specific pericytes), upon activation during liver fibrogenesis give rise to myofibroblasts2-4. We observe significantly enriched localization of BETs to hundreds of super-enhancers associated with genes involved in multiple pro-fibrotic pathways. This unique loading pattern consequentially serves as a molecular mechanism by which BETs modulate pro-fibrotic gene expression in myofibroblasts. Strikingly, suppression of

ORGANISM(S): Homo sapiens

SUBMITTER: Ruth Yu 

PROVIDER: E-GEOD-58680 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress