Expression data from conditional Klf5 knockout Pten-null mouse prostates

ABSTRACT: KLF5 is a basic transcription factor that regulates multiple biological processes, but its function in tumorigenesis appears contradictory in the current literature, with some studies showing tumor suppressor activity and others showing tumor promoting activity. In this study, we examined the function of Klf5 in prostatic tumorigenesis using mice with prostate specific deletion of Klf5 and Pten, both of which are frequently deleted in human prostate cancer. Histological and molecular analyses demonstrated that when one Pten allele was deleted, which causes mouse intraepithelial neoplasia (mPIN), Klf5 deletion accelerated the emergence and progression of mPIN. When both Pten alleles were deleted, which causes prostate cancer, Klf5 deletion promoted tumor growth and caused more severe morpho

ORGANISM(S): Mus musculus

SUBMITTER: Jin-Tang Dong 

PROVIDER: E-GEOD-58719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress