Human proliferating and differentiating keratinocytes treated with retinoic acid or 3,4-didehydroretinoic acid

ABSTRACT: Targets of Retinoic Acid (RA) and 3,4-didehydroretinoic acid (ddRA) were identified in primary human epidermal keratinocytes grown in the presence of atRA or ddRA for 4 and 24 hours. Retinoids (natural forms and synthetic derivatives of vitamin A) are used as therapeutic agents for numerous skin diseases such as keratinization disorders (e.g. ichthyoses) and psoriasis. Two endogenous ligands for retinoic acid receptors exist, retinoic acid (atRA) and 3,4-didehydroretinoic acid (ddRA). In primary human epidermal keratinocytes many transcriptional targets for atRA are known, whereas the targets for ddRA are unknown. In an attempt to determine the targets, we compared the effect of atRA and ddRA on transcriptional profiles in undifferentiated and differentiating human primary keratinocytes.

ORGANISM(S): Homo sapiens

SUBMITTER: Hans Törmä 

PROVIDER: E-GEOD-58749 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress