Cognitive dysfunction and amyloid beta accumulation are ameliorated by the ingestion of green soybean extract in aged mice

ABSTRACT: The prevention or delay of brain senescence would enhance the quality of life for older persons. We investigated the effects of soybean extracts in senescence-accelerated (SAMP10) mice. This mouse is a model of brain senescence with a short life span, cerebral atrophy and cognitive dysfunction. Mice were fed a diet containing soybean extracts from 1 to 12 months of age. The effects of green and yellow soybean extracts were compared with a control diet without soybean extracts. Cognitive functions were higher in aged mice fed green soybean than age-matched control mice and mice fed yellow soybean. We further investigated transcriptome of the SAMP10 hippocampus indicated that expression levels of 36 genes were significantly higher and 19 genes were lower in mice that ingested green soybean t

ORGANISM(S): Mus musculus

SUBMITTER: Tomokazu Konishi 

PROVIDER: E-GEOD-58811 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress