Coordinated epigenetic remodelling occurs during early breast carcinogenesis [ChIP-seq & MBD-Seq]

ABSTRACT: Dysregulation of the epigenome is a common event in malignancy. However, deciphering the earliest cancer associated epigenetic events remains a challenge. Cancer epigenome studies to date have primarily utilised cancer cell lines or clinical samples, where it is difficult to identify the initial epigenetic lesions from those that occur over time. Here, we analysed the epigenome of normal Human Mammary Epithelial Cells (HMEC) and a matched variant cell population (vHMEC) that has escaped senescence and undergone partial carcinogenic transformation. Using this model system we sought to identify the earliest epigenetic changes that potentially occur during carcinogenesis. First we show that the transcriptome of vHMEC resembles that of basal-like breast cancer. Moreover, in vHMEC there is sign

ORGANISM(S): Homo sapiens

SUBMITTER: Warwick Locke 

PROVIDER: E-GEOD-58881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress