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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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M12-8: MRX34 Biomarker study in animals bearing Hep3B orthotopic liver tumors [Illumina]

ABSTRACT: To identify direct tumor mRNA targets of miR-34a, tumor RNAs isolated from whole tumors from animals treated with negative control and MRX34 Hep3B cells were surgically implanted into the livers of Nod/Scid mice and allow to grow for multiple weeks. Once serum AFP levels reached levels consistent with tumor growth of ~80-100 mg, animals were subjected to a single IV injection of MRX34. Twenty-four hours later animals were sacrificed, tumors resected and RNA isolated for subsequent microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Daige

PROVIDER: E-GEOD-58892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Systemic delivery of a miR34a mimic as a potential therapeutic for liver cancer.

Daige Christopher L CL Wiggins Jason F JF Priddy Leslie L Nelligan-Davis Terri T Zhao Jane J Brown David D

Molecular cancer therapeutics 20140722 10

miR34a is a tumor-suppressor miRNA that functions within the p53 pathway to regulate cell-cycle progression and apoptosis. With apparent roles in metastasis and cancer stem cell development, miR34a provides an interesting opportunity for therapeutic development. A mimic of miR34a was complexed with an amphoteric liposomal formulation and tested in two different orthotopic models of liver cancer. Systemic dosing of the formulated miR34a mimic increased the levels of miR34a in tumors by approximat ...[more]

PMID: 25053820

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MRX34 Biomarker study in animals bearing Hep3B orthotopic liver tumors

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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M12-8: MRX34 Biomarker study in animals bearing Hep3B orthotopic liver tumors [Illumina]

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