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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms

ABSTRACT: Comparision of mRNA abundance and translation efficiency mediated by cytoplasmic poly(A) polymerases in C. elegans comparision of different adults treated with RNAi

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Marco Nousch

PROVIDER: E-GEOD-58918 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms.

Nousch Marco M Yeroslaviz Assa A Habermann Bianca B Eckmann Christian R CR

Nucleic acids research 20140912 18

Post-transcriptional gene regulation mechanisms decide on cellular mRNA activities. Essential gatekeepers of post-transcriptional mRNA regulation are broadly conserved mRNA-modifying enzymes, such as cytoplasmic poly(A) polymerases (cytoPAPs). Although these non-canonical nucleotidyltransferases efficiently elongate mRNA poly(A) tails in artificial tethering assays, we still know little about their global impact on poly(A) metabolism and their individual molecular roles in promoting protein prod ...[more]

PMID: 25217583

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