NLRP3 inflammasome activation-responsive genes in a human monocyte cell line THP-1

ABSTRACT: Inflammasome, activated by pathogen-derived and host-derived danger signals, constitutes a multimolecular signaling complex that serves as a platform for caspase-1 (CASP1) activation and interleukin-1beta (IL1B) maturation. The activation of NLRP3 inflammasome requires two-step signals. The first “priming” signal (Signal 1) enhances gene expression of inflammasome components. The second “activation” signal (Signal 2) promotes the assembly of inflammasome components. Deregulated activation of NLRP3 inflammasome contributes to the pathological processes of Alzheimer’s disease (AD) and multiple sclerosis (MS). However, at present, the precise mechanism regulating NLRP3 inflammasome activation and deactivation remains largely unknown. By genome-wide gene expression profiling, we studied the mo

ORGANISM(S): Homo sapiens

SUBMITTER: Jun-ichi Satoh 

PROVIDER: E-GEOD-58959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress