Expression profile of BCR-ABL1-transformed, Cdk4 R24C, Cdk6 R31C cell lines

ABSTRACT: Cdk4 and Cdk6 are two related kinases that bind D-type cyclins and regulate cell cycle progression. Due to their relevance in cancer, Cdk4/6 inhibitors are currently in advanced clinical trials in multiple tumor types. Cdk4/6 are inhibited by INK4 proteins that exert tumor suppressing functions. To test the significance of this inhibitory mechanism we have generated knock-in mice that express a Cdk6 mutant (Cdk6 R31C) insensitive to INK4-mediated inhibition. Cdk6R/R mice display altered development of the hematopoietic system without resulting in enhanced tumor susceptibility, either in the presence or absence of p53. The presence of the Cdk6 R31C allele results in defective potential of hematopoietic progenitors in adoptive transfer assays or after induced damage. These defects are rescue

ORGANISM(S): Mus musculus

SUBMITTER: Marcos Malumbres 

PROVIDER: E-GEOD-59024 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress