Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression profiling of microRNA and mRNA on hepatic inflammation in high-fat induced murine model

ABSTRACT: The goal of this study was to identify and characterize of miRNA in the regulation of inflammatory responses of high-fat induced inflammation mouse model. In this study, we established a mouse model of high-fat-diet-induced inflammation to gain understanding on the biological functions deregulated by aberrant gene expression based on miRNA and mRNA expression profiling analysis. And then we looked for direct miRNA targets by performing pair-wise correlation coefficient analysis on expression levels of mRNAs and by comparing these results with predicted miRNA targets from TargetScan5.1. A subset of the mice from the Chow and HFD groups were killed after 3 months and 9 months. All animals were weighed and anesthetized with ether. Serum was then obtained from the retro-orbital cavity, and mice were killed before liver tissue collection.

ORGANISM(S): Mus musculus

SUBMITTER: Minhyung Kim 

PROVIDER: E-GEOD-59042 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway.

Hur Wonhee W   Lee Joon Ho JH   Kim Sung Woo SW   Kim Jung-Hee JH   Bae Si Hyun SH   Kim Minhyung M   Hwang Daehee D   Kim Young Seok YS   Park Taesun T   Um Soo-Jong SJ   Song Byoung-Joon BJ   Yoon Seung Kew SK  

The international journal of biochemistry & cell biology 20150507

Mechanisms associated with the progression of non-alcoholic fatty liver disease (NAFLD) remain unclear. We attempted to identify the pattern of altered gene expression at different time points in a high fat diet (HFD)-induced NAFLD mouse model. The early up-regulated genes are mainly involved in the innate immune responses, while the late up-regulated genes represent the inflammation processes. Although recent studies have shown that microRNAs play important roles in hepatic metabolic functions,  ...[more]

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