Comparison of transcriptomes of pre-ameloblasts (PAB) and secretory ameloblasts (SAB) in tooth development

ABSTRACT: Background: Ameloblast differentiation is the most critical stepwise process in amelogenesis and controlled by a precisely molecules synergistically. To better understand the molecular events defining cell differentiation between preameloblasts and secretory ameloblasts during amelogenesis, a more precise identification of molecules and signaling networks would shed light on the mechanisms governing enamel formation and help lay a foundation for enamel regeneration. Results: Gene expression profiles of human preameloblast and secretory ameloblast cells were obtained using human genome microarrays. From a total of 28,869 analyzed transcripts, 923 differentially expressed genes (DEGs) with FDR<0.01 and Fold-change > 2 were obtained. Among them, more than twice DEGs were found enriched in PAB

ORGANISM(S): Homo sapiens

SUBMITTER: Yulong Niu 

PROVIDER: E-GEOD-59214 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress