Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development
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ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Robert Lowe
PROVIDER: E-GEOD-59222 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development.
Lowe Robert R Gemma Carolina C Rakyan Vardhman K VK Holland Michelle L ML
BMC genomics 20150414
<h4>Background</h4>As sex determines mammalian development, understanding the nature and developmental dynamics of the sexually dimorphic transcriptome is important. To explore this, we generated 76 genome-wide RNA-seq profiles from mouse eight-cell embryos, late gestation and adult livers, together with 4 ground-state pluripotent embryonic (ES) cell lines from which we generated both RNA-seq and multiple ChIP-seq profiles. We complemented this with previously published data to yield 5 snap-shot ...[more]
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