Gene expression data from SOX2 knock-out 2102Ep and NTera-2 human embryonal carcinoma cell lines

ABSTRACT: SOX2 is an oncogene and a core pluripotency transcription factor. SOX2 has multiple roles in various malignancies, in the maintainance of pluripotency and during various stages of embryonic development. Human embryonal carcinoma cells express SOX2 and the loss of this results in their differentiation. We silenced SOX2 in two human embryonal carcinoma cell lines and measured whole-genome mRNA expression. Many genes related to embryogenesis and tissue morphogensis were upregulated. Other upregulated genes were markers of mesodermal development and epithelial-to-mesenchymal transition. A specific and validated siRNA against SOX2 was chemically transfected in undifferentiated 2102Ep and NTera-2 embryonal carcinoma cell lines. After three days of incubation under normal growth conditions we use

ORGANISM(S): Homo sapiens

SUBMITTER: Sebastian Vencken 

PROVIDER: E-GEOD-59234 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress