Molecular features of subtype-specific progression from ductal carcinoma in situ to invasive breast cancer [gene expression data]

ABSTRACT: Breast cancer consists of at least five main molecular “intrinsic” subtypes, which are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of invasive breast cancer are established early, it is unclear what mechanisms drive progression, and whether the mechanisms of progression are dependent or independent of subtype. We have generated mRNA, miRNA and DNA copy number profiles from a total of 59 in situ lesions and 85 invasive tumors, in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. Our work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic subtyp

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Lesurf 

PROVIDER: E-GEOD-59246 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress