WT and ATRX KO
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jim Hughes
PROVIDER: E-GEOD-59271 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.
Voon Hsiao P J HP Hughes Jim R JR Rode Christina C De La Rosa-Velázquez Inti A IA Jenuwein Thomas T Feil Robert R Higgs Douglas R DR Gibbons Richard J RJ
Cell reports 20150409 3
Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin and telomeres. The role of H3.3 at heterochromatic regions is unknown, but mutations in the ATRX/Daxx/H3.3 pathway are linked to aberrant telomere lengthening in certain cancers. In this study, we show that ATRX-dependent deposition of H3.3 is no ...[more]
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