Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

ABSTRACT: Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock.M-BM- We have determined the underlyingM-BM- mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased examination of eRNAs that cluster in specific circadian phasesM-BM- identified functional enhancers driven by distinct transcription factors (TFs). We further identify on a global scale the components of the TF cistromes that function to orchestrate circadian gene expression. Integrated genomicM-BM- analysesM-BM- also revealed novel mechanisms by which a single circadian factor controls opposing transcriptional phases. These findings shed new light on the diversity and specificity of

ORGANISM(S): Mus musculus

SUBMITTER: Bin Fang 

PROVIDER: E-GEOD-59486 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress