Post-transcriptional microRNA modifications in the Dengue mosquito vector, Aedes aegypti

ABSTRACT: MicroRNAs (miRNA) have alternative forms known as isomiRs, which differ from each other by a few nucleotides. Next generation sequencing platforms facilitate identification of these isomiRs and recent discoveries regarding their functional importance have increased our understandings of the regulatory complexities of the microRNAome. Observed changes in the miRNA profiles in mosquitoes infected with flaviviruses have implicated small RNAs in the interactions between viruses and their vectors. Here we analysed the isomiR profiles of both uninfected and infected blood fed Aedes aegypti mosquitoes with a major human pathogen, Dengue virus at two time points post-infection. We found noticeable changes to the isomiR expression profile in response to infection and aging. Data analysis revealed a

ORGANISM(S): Aedes aegypti

SUBMITTER: Kayvan Etebari 

PROVIDER: E-GEOD-59516 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress