DNA methylation changes in fetal germ cells exposed to endocrine disruptors and in the next generation [methylation set 2]

ABSTRACT: According to recent reports, exposure to environmental endocrine disrupting chemicals (EDs) during pregnancy may harm multiple subsequent generations. We hypothesized that EDs must directly alter DNA methylation and/or transcription in the exposed fetal germ cells to affect the grandchild. In addition, the aberrant pattern must be retained in the germ cells of the grandchild -- withstanding global epigenome remodeling -- to affect the great-grandchild. To test this hypothesis, we extensively searched for immediate and persistent epigenetic effects in purified germ cells of the exposed fetus and those of the next generation. We treated gestating female mice with previously validated doses of vinclozolin (VZ), bisphenol A (BPA), di-(2-ethylhexyl) phthalate (DEHP), or control oil, during the

ORGANISM(S): Mus musculus

SUBMITTER: Piroska Szabo 

PROVIDER: E-GEOD-59542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress