THOC5 controls 3M-BM-4end-processing of immediate early genes via interaction with CPSF100

ABSTRACT: Transcription of immediate early genes (IEGs) in response to extrinsic and intrinsic signals is tightly regulated at multiple stages. THOC5, a member of the TREX (transcription/export) complex plays a role in expression of only a subset of constitutively active genes. In this report, we show that THOC5 plays a role in the 3M-BM-4end-processing of more than 90% of IEGs induced by serum stimulation, however THOC5 depletion does not influence the expression of the most rapidly induced IEGs, such as Fos or Jun. One group of THOC5 target genes, including Id1, Id3 and Wnt11 transcripts were not released from chromatin in THOC5 depleted cells. Another group of genes, such as Myc, and Smad7 transcripts, were released with shortening of 3M-BM-4UTR by alternative cleavage, and were spliced but were

ORGANISM(S): Mus musculus

SUBMITTER: Oliver Dittrich-Breiholz 

PROVIDER: E-GEOD-59561 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress