LDLR-/- mice aorte: Control vs DHA

ABSTRACT: The omega-3 fatty acid docosahexaenoic acid (DHA) has potent anti-atherogenic properties but its mechanisms of action at the vascular level remain poorly explored. Knowing the broad range of molecular targets of omega-3 fatty acids, microarray analysis was used to open-mindedly evaluate the effects of DHA on aorta gene expression in LDLR-/- mice and better understand its local anti-atherogenic action . Mice were fed an atherogenic diet and received daily oral gavages with oils rich in oleic acid or DHA. Bioinformatics analysis of microarray data first identified inflammation and innate immunity as processes the most affected by DHA supplementation within aorta. More precisely, several down-regulated genes were associated with the inflammatory functions of macrophages (e.g. CCL5, CCR7), cel

ORGANISM(S): Mus musculus

SUBMITTER: CM-CM-)cile Gladine 

PROVIDER: E-GEOD-59661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress