Expression analysis of superior cervical ganglion from backcrossed TH-MYCN transgenic mice

ABSTRACT: Neuroblastoma susceptibility in TH-MYN mice is heavily influence by mouse strain background. We have combined linkage analysis of tumor susceptibility with expression QTL analysis of superior cervical ganglia (pure peripheral symptathetic nervous tissue) to identify genes underlying tumor formation The development of targeted therapeutics for neuroblastoma, the third most common tumor in children, has been limited by a poor understanding of growth signaling mechanisms unique to the peripheral nerve precursors from which tumors arise. In this study, we combined genetics with gene expression analysis in the peripheral sympathetic nervous system to implicate arginase 1 and GABA signaling in tumor formation in vivo. In human neuroblastoma cells, activation of GABA-A receptors by a benzodiaz

ORGANISM(S): Mus musculus

SUBMITTER: William Weiss 

PROVIDER: E-GEOD-59675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress