Affymetrix SNP 250K array data for paediatric high grade gliomas

ABSTRACT: Alkylating agents are a frontline therapy for the treatment of several cancers including pediatric glioblastoma, a devastating lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving normal cells unharmed; increasing therapeutic response while minimizing toxicity. Here we report using a siRNA screen targeting over 240 DNA damage response genes identified novel sensitizers to alkylating agents. In particular the base excision repair (BER) pathway, including 3-methylpurine-DNA glycosylase (MPG), as well as ataxia telangiectasia mutated (ATM) were identified in our screen. Interestingly, we identified MPG as a direct novel substrate of ATM. ATM-mediated phosphorylation of MPG w

ORGANISM(S): Homo sapiens

SUBMITTER: Pawel Buczkowicz 

PROVIDER: E-GEOD-59678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress