Curcumin Effectively Depletes Hepatic Cancer Stem-Like Cells

ABSTRACT: The cancer stem cells (CSCs) have important therapeutic implications for multi-resistant cancers including hepatocellular carcinoma (HCC). Among the key pathways frequently activated in liver CSCs is NF-kB signaling. Here we evaluated the CSCs-depleting potential of NF-kB inhibition in liver cancer achieved by IKK inhibitor curcumin and specific peptide SN50 . The effects on CSCs were assessed by analysis of Side Population (SP) and expression levels of CSC-related genes as determined by RT-qPCR, gene expression microarray, EMSA, and Western blotting. Curcumin caused anti-proliferative and pro-apoptotic responses directly related to the extent of NF-kB inhibition. In curcumin-sensitive tumor cells, the treatment led to a selective CSC depletion as evidenced by a reduced SP size, decrease

ORGANISM(S): Homo sapiens

SUBMITTER: Jens Marquardt 

PROVIDER: E-GEOD-59713 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress