Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress

ABSTRACT: The TET-family enzymes (TETs) convert methylcytosine to hydroxymethylcytosine, a lately discovered epigenetic modification that can modulate transcription. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain. Here we show that Tet1 is sensitive to peroxide and report a global decrease in hydroxymethylcytosine in cells treated with BSO and in the intestinal epithelium of mice lacking the major antioxidant enzymes glutathione peroxidases 1 and 2. Furthermore, genome-wide profiling revealed differentially hydroxymethylated regions in genes involved in responses to oxidative stress. Intriguingly, a considerable proportion of these regions lie in genes encoding microRNAs predicted to target transcripts involved in oxidative stress

ORGANISM(S): Homo sapiens

SUBMITTER: Matthieu Defrance 

PROVIDER: E-GEOD-59718 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress