Gene expression profiling in response to radiation treatment in breast cancer [cell lines]

ABSTRACT: Introduction: Breast radiotherapy is currently â??one size fits allâ?? regardless of breast cancer subtype (eg. luminal, basal). However, recent clinical data suggests that radiation response may vary significantly among subtypes. Therefore, current practice leads to over- or under-treatment of women whose tumors are more or less radiation responsive. We hypothesized that this clinical variability may be due, in part, to differences in cellular radiation response. Methods: We exposed 16 biologically-diverse breast tumor cell lines to 0 or 5GY radiation. Microarray analysis was performed on RNA harvested from those cell lines. Samples were run in triplicate. Following quality assessment, differential gene expression analysis was performed using a two-way multiplicative linear mixed-effec

ORGANISM(S): Homo sapiens

SUBMITTER: Janet Horton 

PROVIDER: E-GEOD-59732 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress