Functional phenotypes alteration on dendritic cells between tolerance and immnunity

ABSTRACT: Dendritic cells (DC) are key regulators of immunological responses, immunity and tolerance. Due to their differentiation capacities, they have emerged as a promising tool for therapeutic applications. However, there are poorly understood functional DC-specific markers and cellular mechanisms for in-vitro research and clinical usage. This studyM-bM-^@M-^Ys aim is to evaluate the gene expression profiling of up-regulated or down-regulated by DC maturation and explore their function. The dendritic cells were prepared using GM-CSF and IL-4 (imDC) and subsequently maturated by adding type II collagen as antigen with LPS (mDC) or TNF-alpha(tDC). Also, surface markers, cytokine profiles, and induction of Treg cell were examined in same DC. Then, transcriptional profile was analyzed by using

ORGANISM(S): Mus musculus

SUBMITTER: Dae-seog Lim 

PROVIDER: E-GEOD-59754 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress