Expression data from mouse embryonic stem cells across a time course of Erk stimulation

ABSTRACT: Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for the differentiation of embryonic stem cells (ESCs) to all somatic lineages. To dissect the role of Erk in both ESC self-renewal and lineage specification we explore the requirements for this pathway in various in vitro differentiation settings. A combination of pharmacological inhibition of Erk signaling and genetic loss of function experiments reveal a role for Erk signaling in suppressing endodermal differentiation, but not neural specification. Activation of Erk signaling in ESCs de-represses primitive endoderm (PrE) gene expression as a consequence of inhibiting the pluripotent/epiblast network. The early response to Erk activation correlates with functional PrE pri

ORGANISM(S): Mus musculus

SUBMITTER: Josh Brickman 

PROVIDER: E-GEOD-59755 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress