Open chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Dnase-Seq]

ABSTRACT: The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide maps of open chromatin in primary human fetal epididymis epithelial cells to identify potential regulatory elements controlling coordinated gene expression in the epididymis epithelium. Subsequent in silico analysis identified transcription factor binding sites (TFBS) that were over-represented in the HEE open chromatin, include the motif for paired box 2 (PAX2). PAX2 is a critical transcriptional regulator of urogenital tract development, which is well studied in the kidney but is unexplored i

ORGANISM(S): Homo sapiens

SUBMITTER: Ann Harris 

PROVIDER: E-GEOD-59782 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress