Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Minghui He
PROVIDER: E-GEOD-59813 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell stem cell 20141009 5
Reactivation of the pluripotency network during somatic cell reprogramming by exogenous transcription factors involves chromatin remodeling and the recruitment of RNA polymerase II (Pol II) to target loci. Here, we report that Pol II is engaged at pluripotency promoters in reprogramming but remains paused and inefficiently released. We also show that bromodomain-containing protein 4 (BRD4) stimulates productive transcriptional elongation of pluripotency genes by dissociating the pause release fa ...[more]