Transcriptome profiling of developing photoreceptor subtypes reveals candidate genes for avian photoreceptor diversification

ABSTRACT: Purpose: Avian photoreceptors are a diverse class of neurons, comprised of four single cones, the two members of the double cone, and rods. Many distinctive features of photoreceptor subtypes, including spectral tuning, oil droplet size and pigmentation, synaptic targets and spatial patterning, have been well characterized, but the molecular mechanisms underlying these attributes have not been explored. Furthermore, the signaling events and transcriptional regulators driving the differentiation of these diverse photoreceptors are currently unknown. Methods: To identify genes specifically expressed in distinct chicken (Gallus gallus) photoreceptor subtypes, we developed fluorescent reporters that label photoreceptor subpopulations, isolated these subpopulations using fluorescence-activated

ORGANISM(S): Gallus gallus

SUBMITTER: Jennifer Enright 

PROVIDER: E-GEOD-59850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress