Control of developmentally primed erythroid genes by combinatorial corepressor actions

ABSTRACT: How transcription factors (TFs) cooperate within large protein complexes to allow rapid modulation of gene expression during development is still largely unknown. Here we show that the key haematopoietic LIM-domain-binding protein-1 (LDB1) TF complex contains several activator and repressor components that together maintain an erythroid-specific gene expression programme primed for rapid activation until differentiation is induced. A combination of proteomics, functional genomics and in vivo studies presented here identifies known and novel co-repressors, most notably the ETO2 and IRF2BP2 proteins, involved in maintaining this primed state. The ETO2â??IRF2BP2 axis, interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of the vast majority of archetypical erythroid

ORGANISM(S): Mus musculus

SUBMITTER: Supat Thongjuea 

PROVIDER: E-GEOD-59859 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress