Transcription profiling of human intratumoral samples from central and invasive regions of seven widely invasive PTCs and normal thyroid tissue

ABSTRACT: Papillary thyroid cancers (PTC) that invade into local structures are associated with a poor prognosis, but the mechanisms for PTC invasion are incompletely defined limiting the development of new therapies. To characterize biological processes involved in PTC invasion, we analyzed the gene expression profiles of microscopically dissected intratumoral samples from central and invasive regions of seven widely invasive PTCs and normal thyroid tissue by oligonucleotide microarray and performed confirmatory expression and functional studies. In comparison to the central regions of primary PTCs, the invasive fronts overexpressed TGF ï€� ï€¬ï€� NFb and integrin pathway members, and regulators of small G-proteins and CDC42. Moreover, reduced levels of mRNAs encoding proteins invol

ORGANISM(S): Homo sapiens

SUBMITTER: Sandya Liyanarachchi 

PROVIDER: E-GEOD-6004 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress